How many words start with PY?

20, from 5 letters up to 5. All of them are on this page.

What is the highest scoring word that start with PY?

PYXED at 18 points in Scrabble, and PYXED at 18 in Words With Friends, because the two games score the tiles differently.

PYATS, PYETS, PYGAL, PYGMY, PYINS, PYLON, PYNED, PYNES, PYOID, PYOTS and 10 more on this page.

There are 20 of them. The highest scoring is PYXED at 18 points in Scrabble, and the set averages 12.3.

Most common words first, then the rest A to Z.

The most familiar words on this page and what they mean. Tap any word for its full entry, score and anagrams.

PYGMY noun an unusually small individual
PYLON noun a tower for guiding pilots or marking the turning point in a race
PYRES noun form of PYRE: wood heaped for burning a dead body as a funeral rite
PYXES noun form of PYX: a chest in which coins from the mint are held to await assay
PYXIE noun creeping evergreen shrub having narrow overlapping leaves and early white star-shaped flowers
PYXIS noun fruit of such plants as the plantain

Definitions from Open English WordNet, CC BY 4.0.

All of them: Word lists.